Prof. Hu Junqing, dean of College of Health Science and Environmental Engineering, Shenzhen Technology University (SZTU), published an article titled “A synergistic chemodynamic–photodynamic-photothermal therapy platform based on biodegradable Ce-doped MoOx nanoparticles” in Nanoscale (IF: 8.307) on September 7, together with Assistant Prof. Ha Enna as co-corresponding authors. Doctoral student Li Danyang from College of Health Science and Environmental Engineering is the first author and SZTU is the first affiliation. The full text of the article can be found at: https://pubs.rsc.org/en/content/articlelanding/2022/NR/D2NR03479D.
Schematic illustration of Ce-doped MoOx NPs for synergistic CDT/PDT/PTT antitumor therapy [Photo/https://pubs.rsc.org/en/content/articlelanding/2022/NR/D2NR03479D]
Cancer is currently one of the critical illnesses which is a threat to human beings owing to malignant proliferation by tumor cells. The tumor microenvironment exhibits several distinctive features from normal physiological tissue, including a slightly acidic environment, high concentration of hydrogen peroxide (H2O2), lack of oxygen, and overexpression of glutathione (GSH) and enzymes. Although these features impact or limit cancer treatments, they provide possibilities for cancer diagnosis and new therapeutic strategies. The researchers prepared Ce-doped MoOx (CMO) nanomaterials based on the pH-responsive behavior of MoOx and its localized surface plasmon resonance (LSPR). The obtained CMO nanomaterials show high catalytic activities and high absorption in the NIR II regime. Moreover, due to the doping of Ce element, the consumption of hydrogen peroxide (H2O2) and glutathione (GSH) is boosted. Under NIR II laser irradiation, the designed CMO nanocatalysts induce metabolism disruption and mitochondrial damage in the tumor cells. These properties make CMO nanomaterials ideal biodegradable nanotheranostic agents for synergistic chemodynamic–photodynamic–photothermal antitumor therapy.
Nanoscale is a high-impact international journal, publishing high-quality research across physics, chemistry, biology, medicine, materials, energy/environment, information technology, detection science, healthcare and drug discovery, and electronics. Launched in 2009, Nanoscale is a collaborative venture between the Royal Society of Chemistry Publishing and the National Center for Nanoscience and Technology (NCNST), the latter of which is a leading nanoscience research center located in Beijing, China.
Drafted by Daisy（姚琦）/ International Cooperation & Student Affairs Office
Revised by International Cooperation & Student Affairs Office
Edited by International Cooperation & Student Affairs Office